
Bill, age 74, has numerous skin lesions over his face, arms and hands from many years in the construction industry. He has noticed that one on his right thumb has become thick, raised and firm.
SCC. SCC frequently occurs within an actinic keratosis, becoming thickened as it infiltrates. It may form a keratinous nodule or an erythematous plaque. It can ulcerate. Treatment is generally excision, or radiotherapy. Metastatic disease is possible.

Jim, age 64, presents with acute painless visual loss in the left eye. Jim has a history of type 2 diabetes, hypertension and hypercholesterolemia, but he does not take his medication. On examination, there is an absent red reflex in the left eye.